Do you mean as a USB audio interface? I haven’t tried it like that yet, so far I’ve only been using it into my (analogue) mixer.
I guess it would have to show as two input channels? For me in Logic I would set those up on two separate mono inserts if I didn’t want it as a stereo pair. If that’s possible. I just rarely do that sort of thing, I use a Focusrite Saffire that has its own mix control application that lets me pan / pair / do all sorts of stuff to all the various ins and outs. I guess you would have to create an aggregate device maybe?