It only uses CCs / NRPNs / and Program Changes to communicate…I usually have my DN connected to my iMac and then I route the iPad’s Network MIDI Port to the iMac / DN…you can connect it directly as well. I don’t use OverBridge, but I guess in that case you would need to route the MIDI through the VST?
At the end of the day, the app shows you all available MIDI Input / Output ports detected. It’s up to you to route to / from the DN in whatever configuration you have.