So funny you say that because I just boxed up my Yamaha Reface CS because I’m not using it lately. It was the only keyboard I had it my setup.
I did previously have my Reface sending midi to my Virus C, which sits at an upright angle. The 2 looked similar to an ms20 setup. I do like the ergonomics of that type of setup, but it’s no deal breaker for me. I use my Digitone to sequence notes and play them in live, it lays completely flat. Pushing in the Elektron encoders may be better suited to laying flat then at an angle, but I’ve only tried them flat, therefore I’m only speculating.