first of all, maybe. it can work flawlessly, but remember, it is still a beta version.
ableton live is supported the best, at the moment.
be aware of operating systems. on windows you need win 10! on mac there were also problems with different versions… take a look at the overbridge requirements and best practices, its all online.
for example it is not recommended to send normal midi and get the audio via the plugin… i guess it is latency related.
also i think the clock/jitter of rytm standalone will always be tighter than any clock from computer (via usb) and with overbridge ableton is the master…
when i multitrack record, everything is tight on the grid, but there sure is some latency compensation going on, it is the nature of the process…
i have rytm mk1, win 10 and ableton live and latest beta runs great on my system. if you want to get all 8 audio channels from rytm, you have to use 16bit (not 24bit, because of usb bandwith) and need one pair of free analog inputs on your audio interface if you also want to record the fx channel.
in general i would only use the internal rytm sequencer and only send parameter automation or lfos from ableton to rytm, because the sequencer is superb and tightly integrated on the elektrons…