If Iām not sampling directly from the DT Inputs I always prepare my samples in Renoise.
So in Renoise I created a matrix of around 30 of my favourite effect plugins, all of them disabled and as I need, Iāll activate them and move them around depending on what Iām looking for. Then I load samples that I want to work with in the sampler, and try to take the best character out of each one. If the sample is stereo Iāll find if sounds better from the L or R or SUM LR. I work always in 24/88 and at the end convert down to 16/48.
Suming the LR will not give you the best results every time. You can definitely loose the definition and impact of the sample by doing so because you can have conflic of frequencies that will cancel or sum.
For this kind of analytical work I like to use Etymotic ER4XR headphones paired to DAC/Headphone amp Chord Mojo. Thereās a great synergy between them that lets me ear every detail to extreme. Reverb and compression becomes easier to dial and find the perfect spot. Iām super grateful to own such equipment