Okay, I have had the U-24 hooked up with the iPad and OTMKII for an hour or so testing things out and so far so good!
My intent with this interface box was to utilize the iPad as an effects processor for OT output that I could then route back in for resampling, also to utilize other iOS synths and noise making apps as sampling source material for OT input. May come up with additional uses as things progress.
One thing that I will have to pay attention to are all the additional gain stages that come into the picture now with the U-24. Each input channel on the U-24 has gain level knobs, there is the main out volume, the headphone volume, the USB/MAIN output balance, the USB Computer before/after audio balance etc. There is certainly a lot of flexibility all around with this U-24.