I’m not who you asked, but Bitwig works with Overbridge. I don’t use it much personally, but it definitely works well. There is some latency, but I don’t think it’s from the choice of DAW.
Or were you asking about Reaper? I don’t have any OB+Reaper experience, but I remember reading this thread: https://www.elektronauts.com/t/overbridge-and-reaper
I’m starting to do some more DAW-based things, so I’m probably going to start using Overbridge with the Analog Heat in Bitwig, because it just looks like an easy way to run some audio from the computer through analog distortion without using up a bunch of I/O on interfaces and cables.