I have the AudioFuse Studio as well as the AudioFuse 8pre as a ADAT expander to the studio. (using two toslinks cables to connect them)
The units can be used in stand alone mode, But settings gain for (line inputs) unmuting/muting tracks will require the software to do as well as any routing using the CUE mixes.
As of now there are two cue mixes available on the AudioFuse Studio and one on the 8pre. More will be added in future updates though.
As for routing capabilities compared to RME or MOTO it’s not on the same level i would say, the benefit from both RME and MOTO is that you can use an ipad or any computer hooked up to the network to control them. This is not possible with the Arturia interfaces, i would love to see an ipad app to control them, but i very much doubt that won’t be possible since they lack any network connectivity to enable that.
All in all I’m very happy with the AudioFuse series, it works great and sounds really good. The drivers seems to be stable on both OSX and Windows from my experience.
The audioFuse Studio has some of the best on board controls in this form factor and price range imho.
But if you’r after an interface for completely stand alone mode you’r better off looking towards RME or MOTO imho.