There should be no problem to hook it up.
Check for latencies, if you are using it as an insert FX (DAW --> FX --> DAW).
In a clean electro-magnetic environment connecting balanced units to unbalanced often works fine. To use balanced conncetions becomes important, if the signal-to-noise ratio would suffer by external strong noisy signals. Gear like computers, unsufficiantly shielded electronic units, and cabling can cause electrical interferences, which can degrade the quality of audio signals. Sometimes it helps, to separate strong power lines and computers from weaker signal lines like audio.
The interface should have line-in and line-out level, as well as the FX units, which makes re-amplification unnecessary with respect to the audio-level. Re-amplification would make sense, if you want to add some additional analogue warmth to the signal, which can be achieved using a tube preamp, as an example. Or, if the re-amplification is part of the overall sound design approach.