A4/AK will, indeed, stop the sequencer when loading a new Project.
It doesn’t take too long though. Around 6 seconds.
While that is a manageable amount of down time for a live sequencer, I still prefer to have my entire set in a single project.
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Each of my tunes use 4 patterns, and all of the performance knobs. With the use of mutes and performance knobs for variation, I can get a song out of 4 patterns or less. Some of the performance knob settings I have come up with can completely change the vibe of a song. Other little tricks I do for variation is a little live sequencing of fills, followed by the Reload Pattern command, or I’ll shift all notes on a track left, then right.
This is all done with the goal of getting the most out of just 4 patterns, because this way I can fit 32 songs in a single project which is around 90+ minutes of music.
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My other recommendation is before every gig to make a copy of your project for that performance only. That way you can take things far out with tweaks and variation and not have to worry about its saved state during performance, and still have the original in tact.

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