It’s the difference between “sampler” and “synth”.

A sample is a recording and in case of a synth patch this will be exactly a recording of one of many possible patch variations. Modifying a sample later is IMO somehow limited. Depending on the sampler we can have many FX possibilities, but this does IMO not compare to change a synth patch.

A synth allows deep modulation/change of the patch/sound all the time. We can change and edit the patch even in a live-performance, record some automation, and can even edit and modulate the automation live.

This is not better or worse … it’s about the intended sound and sound scapes we want to have.

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