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You get slightly less power, but as far as I know that’s mostly a practical issue for some portable raid drives, not for smaller bus-powered audio interfaces.
Anything big will use its own power supply anyway.
Haven’t heard about any issues with Firewire daisy-chaining, but otoh you might not want to do that too much on the bus your audio interface is connected to anyway.
I see some complaints on the page you link to from people running Windows on their Mac, or from people using the dongle on non-Apple hardware. I hope it’s obvious that that’s not the best idea ever. 