Looks like should be good - from Sweetwater spec:
“Highly Portable and USB Class-compliant
Simply connecting the keyboard over USB is all that’s required to start recording, synthesizing and MIDI controlling. As the device is class compliant, no drivers are required for Windows XP or Mac OSX (although some are provided to improve latency and stability in some apps). Furthermore, if wanting to escape the confines of the studio for a while, the USB cable can be unplugged and the Xio can be powered by batteries, functioning as a standalone synth completely separately from the computer.”