This may be BS but I feel like large speakers might be better in cases where you want to monitor with lower levels, because the sub frequency roll off tends to be quite steep on most speakers, and big 8-inchers or similar will maintain their flatness down to a lower Hz. This means that you can have the output volume set quite low without losing that visceral impact, whereas with 5-inch monitors you may need to turn them up quite loud to feel the impact of the music. This perhaps mostly applies if you’re all about bass heavy music but I feel like that’s quite predomninant these days.
I have a pair of Presonus Eris E8 XT’s which have silk dome tweeters and are quite nice for their price. They have quite a bit more treble than typical hifi speakers so you can definitely still get fatigued if you’re listening too loud for too long.
I think it’s just a tricky thing to balance with studio monitors, you need to be able to hear that high end very clearly to pick out issues and mix, but being that close to such a flat and loud speaker is potentially risky for your hearing. Most of these monitors have adjustable bass and treble pots on the back, so you could always consider turning the high end down a few dB to make it a bit more pleasant on your ears.