Static noise while recording in Ableton


I am trying to record the M:S into Ableton 10 through an audio interface, AudioBox USB by Presonus. I am using ASIO4ALL drivers.
If the USB is plugged in the computer, there is a high pitched static sound coming off the main outs of the M:S going into the audio interface. As soon as I remove the USB, the static goes away. I have tried to send only MIDI through the USB, but so far nothing except removing the cable seems to solve the issue or at least minimize the sound. Is it an electric issue or should I check something in the settings menu?