In the case of sample chains being collections of single shot hits it may be personal preference. Each offers different techniques for changing the currently triggered sample. You can test out how you like using Slices to change the hits vs Changing Sample Slot for ‘single’ samples.

For instance loading up sliced hihat variation sample chain then hitting Create Random Locks can offer some inspiring directions. Assigning a scene to morph Slice number is also great.

On the other side sometimes using single samples and rotating thru Sample Slot on trigs may be the quickest way to lay down an idea.