It does sound like a buffer issue, I ran into the same thing quite often when I was using the Virus TI in my studio. I was able to resolve those issues over the years by always having my TI plugged directly into my Mac (no hub). On a MacBook Pro it's not always that simple (esp with only 2 USB ports) but restrictive systems require sacrifices.
There's a happy medium to be found through testing I think but it's a tradeoff - you might not be able to work in 24-bits for example. Or you might have to only use the Main L/R out instead of individual channels or only work with one piece of Overbridge gear at a time and render your parts separately. There's only so much water that can come out of the faucet.
I'd make sure you open a ticket with Elektron Support all the same, they'll probably have you go through the steps mentioned above.