nah man, definitely not.
personal computers are actually pretty bad at keeping time. pushing out audio at 48kHz on one computer will be slightly slower/faster than on the computer right next to it.

also, you said it yourself - switch off software update etc - there’s ALWAYS the possibility of your OS just doing any random task you have no control over and which might hang/delay something. The OSes we’re using aren’t realtime OSes.

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