Sounds like a grounding issue. When you have a ground loop, all kind of weird (digital) noise can get into your audio signal path.

How are your devices connected to power? Do any of your devices have a 3-prong power plug that includes ground? Is this connected to a power outlet that’s (actually) grounded?

You can try taking devices out of the signal chain to see if that alleviates the issue. From what you describe above, the issue is gone when you unplug the signal that’s going into the OT Input A/B, right?

You might want to read http://www.soundonsound.com/sos/1994_articles/aug94/groundloops.html

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