Loud feedback noise through the A4 entrance

maybe someone understands that !? when I go to the entrances on the A4, e.g. to use the audio interface via ableton, I only get a loud feeback noise back there. the settings on the mixer do not help much. even if i want to connect a pedal to these inputs, you get a loud feedback. the pedal is connected in the conventional way, i.e. output pedal to inputs A4 and A4 outputs to inputs pedal. can it be that the entrances are broken?

With the rytm everything is normal, although the left and right inputs have been merged, but it works perfectly, regardless of whether it is for ableton or pedal.