a quick way to see what you are losing is a quick phase inversion test between the original and the sample thats been repitched. for example in ableton you would start with a sample you want to check, then duplicate it and pitch it up (make sure its not warping so it stretches the sample), then freeze/flatten that, then pitch back down to where it was originally and invert the phase, when you play that new one at the same time as the original you will hear the difference in the phase which will represent the “difference” or what sound you are losing.

in short you lose quite a lot of high mid and most of the high spectrum, though as discussed you can probably compensate with a little processing or layering and whatnot

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