The KP Quad might not have MIDI but it does a damn good job of auto detecting the BPM and failing that it has tap tempo or you can dial it in manually with the dedicated knob. I’ve never seen an issue with this aspect of it.

I have not noticed any loss of signal other than what you would expect from the effect you have applied.

As for connecting it, I personally have it connected to my mixer’s effects send channel so I can select specific instruments that will have the effects applied.