I’ve always been happiest with a minimal setup for studio use but I prefer a hybrid setup where hardware generates ideas and the song is finished in my DAW. I used to have a pretty big setup and even with patchbays for MIDI and audio I feel like the hardware slowed me down and ideas got fuzzy when I couldn’t quickly get something down. And then there was the tendency to want to try and shove each piece of gear into every song while resisting using the DAW/computer for simple things that, lets be honest, no one cares if it came from hardware or not (example: adding finishing touches like reversed hats for risers etc).
My studio process is too slapdash to be coherent in a live setting. I play back and edit mixed stems of my songs using an APC40. However it’s definitely possible to do something improvisational with a few key elements - always been impressed with what Blawan/Karenn pull off. Surgeon also has a rig that he put together specifically for live performances. Here’s a video of him explaining that process: