Only thing I would consider when going the software route is latency. Although it’s down to almost nothing these days, it’s still there. If you’re making quick, live changes, even a few milliseconds can take the punch out of a kick drum drop. or something similar.

I use a hardware compressor with a sidechain input from the OT. Picked up a DBX for $50 on CL and it works and sounds fine.

I tend not to mix the soft- and hardwares - for the reasons I mentioned above.