I personally have a RME Babyface. I either use it’s own XLR inputs (using a blanced TRS - XLR (I know that one is balanced)) and don’t hit 48v or Instrument…OR use my Behringer ADA8000 for only line level inputs.
I always use the gain because it seems that’s the only way to get a loud enough signal from either my AlphaJuno2 or AR.