Well for me personally, I work on computers all the time on audio stuff, so the little time I have for making music I like to work out of the box, but using a DAW to route the midi to everything. I just like to jam and the ability to record individual stems as much as possible is essential. Hopefully One day I’ll get the time & enthusiasm to actually mix finished tracks with the stems. Overbridge has been a marvel in this sense for me and opened a new level of stem recording. Once you have the stems, there’s no need to worry about all of the hardware related setup anymore. It’s really nice to have a clean DAW project with nothing but the WAVs.
As for interfaces, I sold the better ones I had with pre-amps and just got the old Motu 2408’s for just simple line ins. If you are just recording synths, it’s less relevant I think, it’s certainly good enough for my purposes and the results are suitable for itb processing/mixing. If I was making music for a living I would most likely feel differently. These days it’s all about enjoyment and hopefully no technical headaches.